Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus. Issue 28 (24th June 2016)

• Record Type: Journal Article
• Authors: Stephens, Matthew D.; Yodsanit, Nisakorn; Melander, Christian
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 28(2016)
• Page Start: 6853
• Page End: 6856
• Publication Date: 2016-06-24
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob00706f
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A small molecule library consisting of 45 compounds was synthesized based on the bacterial metabolite ethyl N -(2-phenethyl) carbamate. From this library, a more potent, broad-spectrum inhibitor of MRSA biofilm formation was discovered. Abstract : A small molecule library consisting of 45 compounds was synthesized based on the bacterial metabolite ethyl N -(2-phenethyl) carbamate. Screening of the compounds revealed a potent analogue capabale of inhibiting several strains of Methicillin Resistant S. aureus biofilms with low to moderate micromolar IC50 values.