New [(η5-C5H5)Ru(N–N)(PPh3)][PF6] compounds: colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes. Issue 30 (24th May 2016)

• Record Type: Journal Article
• Authors: Florindo, Pedro R.; Pereira, Diane M.; Borralho, Pedro M.; Costa, Paulo J.; Piedade, M. F. M.; Rodrigues, Cecília M. P.; Fernandes, Ana C.
• Is Part Of: Dalton transactions. Volume 45:Issue 30(2016)
• Page Start: 11926
• Page End: 11930
• Publication Date: 2016-05-24
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/c6dt01571a
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : Ruthenium glycoconjugates, with privileged passage through HCT116 colon cancer cell membranes via glucose transporters, are reported. Abstract : Eight ruthenium(ii ) compounds of the general formula [(η 5 -C5 H5 )Ru(N–N)(PPh3 )][PF6 ] were rationally designed, exhibiting high cytotoxicity against HCT116 human colon cancer cells, with IC50 between 14.56 and 1.56 μM; importantly, compounds5Ru and6Ru are the first reported ruthenium glycoconjugates exploiting glucose transporters, widely overexpressed in cancer, for cellular uptake.