Anti-inflammatory effect of a resveratrol derivative 3, 4, 5-trimethoxy-4′, 5′-dihydroxy-trans-stilbene (WL-09-5) via ROS-mediated NF-κB pathway. Issue 10 (2nd October 2016)

• Record Type: Journal Article
• Authors: Ma, Pei; Ding, Ya-Si; Xuan, Ling-Ling; Wang, Lin; Shi, Ji; Bai, Jin-Ye; Lin, Ming-Bao; Zheng, Wen-Sheng; Hou, Qi
• Is Part Of: Journal of Asian natural products research. Volume 18:Issue 10(2016)
• Page Start: 1004
• Page End: 1013
• Publication Date: 2016-10-02
• Subjects: WL-09-5 -- anti-inflammation -- ear edema -- RAW264.7 -- NF-κB; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2016.1181622
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Inflammation derived from macrophages activation leads to various diseases. Synthetic modifications of resveratrol have been shown to have better anti-inflammatory activities. In this study, croton oil-induced mouse ear edema and lipopolysaccharides (LPS)-stimulated RAW264.7 macrophages were used to evaluate the anti-inflammatory effects of WL-09-5, a derivative of resveratrol. Furthermore, the activation of NF-κB was determined. Results showed that WL-09-5 significantly reduced the croton oil-induced ear edema, scavenged NO and ROS production, and reduced the levels of TNF-α, IL-6, and IL-1β. Furthermore, WL-09-5 may significantly inhibit the translocation of NF-κB in macrophage cells stimulated by LPS in a dose-dependent manner, which is a potent mechanism of its anti-inflammatory effects. In conclusion, WL-09-5 is an underlying candidate for inflammatory diseases that need further investigations.