Probing the molecular mechanism of cerium oxide nanoparticles in protecting against the neuronal cytotoxicity of Aβ1–42 with copper ions. Issue 7 (14th December 2015)

• Record Type: Journal Article
• Authors: Zhao, Yaqin; Xu, Qiming; Xu, Wei; Wang, Dandan; Tan, Jason; Zhu, Cuiqing; Tan, Xiangshi
• Is Part Of: Metallomics. Volume 8:Issue 7(2016:Jul.)
• Page Start: 644
• Page End: 647
• Publication Date: 2015-12-14
• Subjects: Metals -- Physiological effect -- Periodicals; 572.51
• DOI: 10.1039/c5mt00242g
• Languages: English
• ISSNs: 1756-5901

Abstract

Abstract : The molecular mechanism of CeONPs in protecting against neuronal cytotoxicity from amyloid peptides and copper ions was investigated systematically by photoluminescence of [Ru(phen)2 dppz] 2+, morphology of TEM, mass spectroscopy, cell viability assay, ROS fluorescence assay, and EPR. Abstract : The molecular mechanism of CeONP in protecting against neuronal cytotoxicity from amyloid peptides and copper ions was investigated systematically by photoluminescence of [Ru(phen)2 dppz] 2+, morphology of TEM, mass spectroscopy, cell viability assay, ROS fluorescence assay, and EPR. The results revealed that CeONPs reduced Aβ1–42 aggregation, protected from neurotoxicity of ROS induced by Cu 2+ + Aβ1–42 via blocking the production of free radicals and scavenging the radicals with Ce 3+ /Ce 4+ catalytic cycles, which provides a valuable insight into CeONPs as a therapeutic intervention in oxidative damage in Alzheimer's disease.