Cyclic dinucleotide (c-di-GMP, c-di-AMP, and cGAMP) signalings have come of age to be inhibited by small molecules. Issue 60 (24th June 2016)

• Record Type: Journal Article
• Authors: Opoku-Temeng, Clement; Zhou, Jie; Zheng, Yue; Su, Jianmei; Sintim, Herman O.
• Is Part Of: Chemical communications. Volume 52:Issue 60(2016)
• Page Start: 9327
• Page End: 9342
• Publication Date: 2016-06-24
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc03439j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Bacteria utilize nucleotide-based second messengers to regulate a myriad of physiological processes. Small molecules that inhibit nucleotide signaling could have antibacterial properties. Abstract : Bacteria utilize nucleotide-based second messengers to regulate a myriad of physiological processes. Cyclic dinucleotides have emerged as central regulators of bacterial physiology, controlling processes ranging from cell wall homeostasis to virulence production, and so far over thousands of manuscripts have provided biological insights into c-di-NMP signaling. The development of small molecule inhibitors of c-di-NMP signaling has significantly lagged behind. Recent developments in assays that allow for high-throughput screening of inhibitors suggest that the time is right for a concerted effort to identify inhibitors of these fascinating second messengers. Herein, we review c-di-NMP signaling and small molecules that have been developed to inhibit cyclic dinucleotide-related enzymes.