Paramagnetic lanthanide chelates for multicontrast MRI. Issue 59 (13th June 2016)

• Record Type: Journal Article
• Authors: Cakić, Nevenka; Savić, Tanja; Stricker-Shaver, Janice; Truffault, Vincent; Platas-Iglesias, Carlos; Mirkes, Christian; Pohmann, Rolf; Scheffler, Klaus; Angelovski, Goran
• Is Part Of: Chemical communications. Volume 52:Issue 59(2016)
• Page Start: 9224
• Page End: 9227
• Publication Date: 2016-06-13
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc04011j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A paramagnetic chelator that serves as a platform for multicontrast MRI is presented. It can be utilized as a T 1 -weighted, paraCEST or 19 F MRI contrast agent. Abstract : The preparation of a paramagnetic chelator that serves as a platform for multicontrast MRI, and can be utilized either as a T 1 -weighted, paraCEST or 19 F MRI contrast agent is reported. Its europium(iii ) complex exhibits an extremely slow water exchange rate which is optimal for the use in CEST MRI. The potential of this platform was demonstrated through a series of MRI studies on tube phantoms and animals.