Synthetic biology — application-oriented cell engineering. (August 2016)

• Record Type: Journal Article
• Authors: Xie, Mingqi; Haellman, Viktor; Fussenegger, Martin
• Is Part Of: Current opinion in biotechnology. Volume 40(2016)
• Page Start: 139
• Page End: 148
• Publication Date: 2016-08
• Subjects: Biotechnology -- Periodicals; 660.6
• DOI: 10.1016/j.copbio.2016.04.005
• Languages: English
• ISSNs: 0958-1669

Abstract

Graphical abstract: Highlights: Synthetic biology creates cell-based solutions for important biomedical problems. Applications range from drug discovery and molecular diagnostics to cell-therapies. Abstract : Synthetic biology applies engineering principles to biological systems and reprograms living cells to perform novel and improved functions. In this review, we first provide an update of common tools and design principles that enable user-defined control of mammalian cell activities with spatiotemporal precision. Next, we demonstrate some examples of how engineered mammalian cells can be developed towards biomedical solutions in the context of real-world problems.