Negative functional coupling between the right fronto-parietal and limbic resting state networks predicts increased self-control and later substance use onset in adolescence. (August 2016)

• Record Type: Journal Article
• Authors: Lee, Tae-Ho; Telzer, Eva H.
• Is Part Of: Developmental cognitive neuroscience. Volume 20(2016)
• Page Start: 35
• Page End: 42
• Publication Date: 2016-08
• Subjects: Adolescence -- Risk-taking behavior -- Resting-state fMRI -- Independent component analysis (ICA) -- Fronto-parietal network (FPN) -- Limbic network -- Intrinsic network connectivity; Cognitive neuroscience -- Periodicals; Developmental neurobiology -- Periodicals; Neuropsychology -- Periodicals; Neuropsychiatry -- Periodicals; 612.8233
• DOI: 10.1016/j.dcn.2016.06.002
• Languages: English
• ISSNs: 1878-9293

Abstract

Abstract: Recent developmental brain imaging studies have demonstrated that negatively coupled prefrontal-limbic circuitry implicates the maturation of brain development in adolescents. Using resting-state functional magnetic resonance imaging (rs-fMRI) and independent component analysis (ICA), the present study examined functional network coupling between prefrontal and limbic systems and links to self-control and substance use onset in adolescents. Results suggest that negative network coupling (anti-correlated temporal dynamics) between the right fronto-parietal and limbic resting state networks is associated with greater self-control and later substance use onset in adolescents. These findings increase our understanding of the developmental importance of prefrontal-limbic circuitry for adolescent substance use at the resting-state network level.