Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors. Issue 16 (15th August 2016)

• Record Type: Journal Article
• Authors: Dwyer, Michael P.; Keertikar, Kerry M.; Chen, Lei; Tong, Ling; Selyutin, Oleg; Nair, Anilkumar G.; Yu, Wensheng; Zhou, Guowei; Lavey, Brian J.; Yang, De-Yi; Wong, Michael; Kim, Seong Heon; Coburn, Craig A.; Rosenblum, Stuart B.; Zeng, Qingbei; Jiang, Yueheng; Shankar, Bandarpalle B.; Rizvi, Razia; Nomeir, Amin A.; Liu, Rong; Agrawal, Sony; Xia, Ellen; Kong, Rong; Zhai, Ying; Ingravallo, Paul; Asante-Appiah, Ernest; Kozlowski, Joseph A.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 26:Issue 16(2016)
• Page Start: 4106
• Page End: 4111
• Publication Date: 2016-08-15
• Subjects: Hepatitis C -- NS5A -- Infectious diseases -- Indole -- Capping; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2016.06.063
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: A matched and mixed capping SAR study was conducted on the tetracyclic indole class of HCV NS5A inhibitors to examine the influence of modifications of this region on the overall HCV virologic resistance profiles.