DABCO-catalyzed one-pot three component synthesis of dihydropyrano[3, 2-c]chromene substituted quinazolines and their evaluation towards anticancer activity. Issue 16 (15th August 2016)

• Record Type: Journal Article
• Authors: Vodnala, Sumathi; Bhavani, A.K.D.; Kamutam, Ramakrishna; Naidu, V.G.M.; Promila, ; Prabhakar, Ch.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 26:Issue 16(2016)
• Page Start: 3973
• Page End: 3977
• Publication Date: 2016-08-15
• Subjects: Multicomponent reaction -- Knoevenagel–Michael reaction -- Quinazoline -- 4-Hydroxycoumarin -- DABCO -- Anti-cancer; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2016.07.003
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: The novel carbon–carbon linked dihydropyrano[3, 2- c ]chromene substituted quinazolines were achieved via DABCO induced Knoevenagel–Michael addition reaction and resulting derivatives were evaluated towards anticancer activity. Abstract: A facile DABCO promoted one-pot three component synthesis of a new series of C–C linked bis-heterocycle containing dihydropyrano[ c ]chromene as highly fused oxa -heteryl group at C-2 position of quinazoline was developed. Quinazoline-2-carbaldehyde, substituted 4-hydroxycoumarin and ethyl cyanoacetate were used as key components in the Knoevenagel–Michael addition reaction to get the titled compounds. These compounds were screened for anti-cancer activity against the breast cancer cell lines of MDA-MB 231, and MDA-MB 453.