FABP1 in wonderland. Issue 3 (22nd June 2016)

• Record Type: Journal Article
• Authors: Prinetti, Alessandro; Mitro, Nico
• Is Part Of: Journal of neurochemistry. Volume 138:Issue 3(2016)
• Page Start: 371
• Page End: 373
• Publication Date: 2016-06-22
• Subjects: Neurochemistry -- Periodicals; 616.8042
• DOI: 10.1111/jnc.13685
• Languages: English
• ISSNs: 0022-3042

Abstract

Abstract : Cannabinoid receptors hold a core position in the brain and control memory, cognition, movement, and pain sensitivity. sn ‐2 arachidonoylglycerol (2‐AG) activates neuronal cannabinoid receptors as a full agonist. The brain may rely on circulating arachidonic acid to synthesize endogenous cannabinoids. This Editorial highlights a study by Martin and coworkers in the current issue of the Journal of Neurochemistry in which the authors describe, for the first time, that liver acts as a pool of arachidonic acid that under certain conditions feeds the brain to produce endocannabinoids. Therapeutics affecting liver FABP1 levels should take into account that FABP1 represents a fatty acid reservoirs for the brain. Read the highlighted article "FABP‐1 gene ablation impacts brain endocannabinoid system in male mice" on page407 . Abstract : Cannabinoid receptors hold a core position in the brain and control memory, cognition, movement, and pain sensitivity. sn ‐2 arachidonoylglycerol (2‐AG) activates neuronal cannabinoid receptors as a full agonist. The brain may rely on circulating arachidonic acid to synthesize endogenous cannabinoids. This Editorial highlights a study by Martin and coworkers in the current issue of the Journal of Neurochemistry in which the authors describe, for the first time, that liver acts as a pool of arachidonic acid that under certain conditions feeds the brain to produce endocannabinoids. Therapeutics affecting liver FABP1 levels should take into account that FABP1 represents a fatty acid reservoirs for the brain. Read the highlighted article "FABP‐1 gene ablation impacts brain endocannabinoid system in male mice" on page407 .