Eradication Rates of Helicobacter pylori in Korea Over the Past 10 years and Correlation of the Amount of Antibiotics Use: Nationwide Survey. Issue 4 (16th October 2015)

• Record Type: Journal Article
• Authors: Shin, Woon Geon; Lee, Sang Woo; Baik, Gwang Ho; Huh, Kyu Chan; Lee, Sang In; Chung, Jun‐Won; Jung, Woon Tae; Park, Moo In; Jung, Hye‐kyung; Kim, Heung Up; Kim, Jeong Hwan; Seol, Sang Young; Yoon, Soon Man; Jeon, Seong Woo; Hong, Su Jin; Kim, Gwang Ha; Lee, Dong Ho; Kim, Hyun Soo; Choi, Suck Chei; Kang, Hee Mo; Lee, Joongyub; Kim, Jae Gyu; Kim, Jae J.
• Is Part Of: Helicobacter. Volume 21:Issue 4(2016:Aug.)
• Page Start: 266
• Page End: 278
• Publication Date: 2015-10-16
• Subjects: Helicobacter pylori -- treatment failure -- trends -- antibiotics; Helicobacter -- Periodicals; Helicobacter infections -- Periodicals; Stomach -- Diseases -- Periodicals; 616.3301405
• DOI: 10.1111/hel.12279
• Languages: English
• ISSNs: 1083-4389

Abstract

Abstract: Background: The efficacy of proton‐pump inhibitor–amoxicillin–clarithromycin therapy for H. pylori eradication has decreased over time. Objective: We assessed the trend of H. pylori eradication rates over the last 10 years and the relationship between the eradication rates and the amount of macrolide antibiotic use in a country with a high prevalence of H. pylori infection. Methods: This vast nationwide multicenter study was conducted with 34, 139 adults treated for H. pylori infection from January 2001 to December 2010. The defined daily dose per km 2 (DSD) of macrolide antibiotics was calculated (n = 141, 019) using the Health Insurance Review & Assessment data base from 2008 to 2010 in the two cities which had the lowest (Jeju city) or highest (Chuncheon city) eradication rate. Results: The eradication rates of proton‐pump inhibitor–amoxicillin–clarithromycin therapy ranged 84.9–87.5% from 2001 to 2007, and those of 2008 to 2010 ranged 80.0–81.4% with a decreasing trend ( p < 0.0001). The decreasing trend of eradication rates for the overall first‐line therapy was observed only in three of the seven geographic areas in Korea ( p < 0.0001). The DSD of macrolide antibiotics was significantly higher in Jeju than Cheunchon city (0.85 vs 0.52, p < 0.0001). Conclusions: H. pylori eradication rates with clarithromycin‐containing triple therapy in Korea showed a decreasing trend over the past 10 years, although the trend varied among geographic areas. This difference may be associated with the amount of macrolide antibiotic use.