Discovery of New Substrates for LuxAB Bacterial Bioluminescence. (21st March 2016)

• Record Type: Journal Article
• Authors: Jiang, Tianyu; Wang, Weishan; Wu, Xingkang; Wu, Wenxiao; Bai, Haixiu; Ma, Zhao; Shen, Yuemao; Yang, Keqian; Li, Minyong
• Is Part Of: Chemical biology & drug design. Volume 88:Number 2(2016)
• Page Start: 197
• Page End: 208
• Publication Date: 2016-03-21
• Subjects: bacterial bioluminescence -- imaging -- luxAB -- new long‐chain aliphatic aldehydes; Drugs -- Design -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; 615.19005
• DOI: 10.1111/cbdd.12747
• Languages: English
• ISSNs: 1747-0277

Abstract

Abstract : In this article, four novel substrates with long halftime have been designed and synthesized successfully for luxAB bacterial bioluminescence. After in vitro and in vivo biological evaluation, these molecules can emit obvious bioluminescence emission with known bacterial luciferase, thus indicating a new promising approach to developing the bacterial bioluminescent system. Abstract : In this article, four novel substrates with long halftime have been designed and synthesized successfully for luxAB bacterial bioluminescence. After in vitro and in vivo biological evaluation, these molecules can emit obvious bioluminescence emission with known bacterial luciferase, thus indicating a new promising approach to developing the bacterial bioluminescent system.