Photocatalytic Aminodecarboxylation of Carboxylic Acids. Issue 20 (19th June 2016)

• Record Type: Journal Article
• Authors: Lang, Simon B.; Cartwright, Kaitie C.; Welter, Richard S.; Locascio, Theresa M.; Tunge, Jon A.
• Is Part Of: European journal of organic chemistry. Issue 20(2016)
• Page Start: 3331
• Page End: 3334
• Publication Date: 2016-06-19
• Subjects: Homogeneous catalysis -- Photocatalysis -- Amination -- Carboxylic acids; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201600620
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : Aminodecarboxylation of unactivated alkanecarboxylic acids has been accomplished utilizing an organic photocatalyst. This operationally simple reaction utilizes readily available carboxylic acids to chemoselectively generate reactive alkyl intermediates that are not accessible via conventional two‐electron pathways. The organic radical intermediates are efficiently trapped with electrophilic diazo compounds to provide aminated alkanes. Abstract : Aminodecarboxylation of unactivated alkanecarboxylic acids has been accomplished utilizing an organic photocatalyst. This operationally simple reaction utilizes readily available carboxylic acids to chemoselectively generate reactive alkyl intermediates that are not accessible via conventional two‐electron pathways.