Exposure to endocrine disrupting chemicals and neurodevelopmental alterations. (10th June 2016)

• Record Type: Journal Article
• Authors: Pinson, A.; Bourguignon, J. P.; Parent, A. S.
• Other Names: Andersson Anna‐Maria guestEditor.; Bay Katrine guestEditor.; Frederiksen Hanne guestEditor.; Grigor Ken guestEditor.; Skakkebaek Niels E. guestEditor.
• Is Part Of: Andrology. Volume 4:Number 4(2016:Jul.)
• Page Start: 706
• Page End: 722
• Publication Date: 2016-06-10
• Subjects: development -- endocrine disruptors -- hormones; Andrology -- Periodicals; 616.65
• DOI: 10.1111/andr.12211
• Languages: English
• ISSNs: 2047-2919

Abstract

Summary: The developing brain is remarkably malleable as neural circuits are formed and these circuits are strongly dependent on hormones for their development. For those reasons, the brain is very vulnerable to the effects of endocrine‐disrupting chemicals (EDCs) during critical periods of development. This review focuses on three ubiquitous endocrine disruptors that are known to disrupt the thyroid function and are associated with neurobehavioral deficits: polychlorinated biphenyls, polybrominated diphenyl ethers, and bisphenol A. The human and rodent data suggesting effects of those EDCs on memory, cognition, and social behavior are discussed. Their mechanisms of action go beyond relative hypothyroidism with effects on neurotransmitter release and calcium signaling.