Atmospheric Pressure Plasma Polymer of Ethyl Lactate: In Vitro Degradation and Cell Viability Studies. Issue 7 (29th March 2016)

• Record Type: Journal Article
• Authors: Laurent, Morgane; Koehler, Julia; Sabbatier, Gad; Hoesli, Corinne A.; Gherardi, Nicolas; Laroche, Gaétan
• Is Part Of: Plasma processes and polymers. Volume 13:Issue 7(2016)
• Page Start: 711
• Page End: 721
• Publication Date: 2016-03-29
• Subjects: biodegradable materials -- cell culture -- dielectric barrier discharge (DBD) -- ethyl lactate -- plasma polymerization; Plasma polymerization -- Periodicals; Plasma-enhanced chemical vapor deposition -- Periodicals; Plasma chemistry -- Periodicals
• DOI: 10.1002/ppap.201500211
• Languages: English
• ISSNs: 1612-8850

Abstract

Abstract : Ethyl lactate is injected into a dielectric barrier discharge (DBD) to build up a degradable plasma polymer (PP) to be used as a drug delivery system. Plasma power, deposition time, and type of carrier gas (Ar, N2 ) are correlated to the coating in vitro degradation rate. PPs are characterized by AFM, SEM, IR spectroscopy, XPS, and SEC, while surface profilometry is used to monitor the degradation kinetics. PPs deposited under N2 are mainly composed of hydrophilic functionalities, which explain their fast degradation upon exposure to an aqueous environment. In contrast, PPs synthesized under Ar lead to a slower degradation rate due to their hydrocarbon structure containing some hydrolyzable moieties. The potential of the PPs for vascular applications is verified through cell viability experiments. Abstract : Degradable plasma polymer coatings are obtained by injecting ethyl lactate into a dielectric barrier discharge. Relations between plasma conditions, chemical composition, and degradation rate of the coatings upon exposure to an aqueous medium are detailed. The toxicity of the degradation products is verified through cell viability assessments to ensure the applicability of the thin films in the vascular field.