Advances in Peptide Functionalization on Mesoporous Silica Nanoparticles for Controlled Drug Release. Issue 25 (6th May 2016)

• Record Type: Journal Article
• Authors: Hu, Jing‐Jing; Xiao, Dong; Zhang, Xian‐Zheng
• Is Part Of: Small. Volume 12:Issue 25(2016)
• Page Start: 3344
• Page End: 3359
• Publication Date: 2016-05-06
• Subjects: drug delivery systems -- silica nanoparticles -- peptides -- targets -- stimuli responsive; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201600325
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : During the last decade, using versatile, promising, and fascinating mesoporous silica nanoparticles (MSNs) as site‐specific and stimuli‐responsive drug delivery systems (DDSs) has received concentrated research interest. As one of the most attractive surface modification units, peptides have inherent bioactivity, biodegradability and biocompatibility. Recent progresses in the utilization of versatile peptides for surface functionalization of MSNs to achieve cell‐specific targeting, fluorescence imaging, and intracellular diagnosis and treatment of tumors are summarized in this review. The various functional peptides decorated on the MSNs are introduced and classified into three types, including targeting peptides, stimuli‐responsive peptides and multifunctional chimeric peptides. The limitations and challenges of peptide modified MSNs and their potential applications are further discussed. Abstract : The latest advances in the utilization of versatile peptides for surface functionalization of mesoporous silica nanoparticles (MSNs) to achieve site‐specific targeting, fluorescence imaging, and intracellular diagnosis, especially controlled release of drugs or genes for tumor treatment are highlighted.