Dietary Supplementation of Ginger and Turmeric Rhizomes Modulates Platelets Ectonucleotidase and Adenosine Deaminase Activities in Normotensive and Hypertensive Rats. (6th May 2016)

• Record Type: Journal Article
• Authors: Akinyemi, Ayodele Jacob; Thomé, Gustavo Roberto; Morsch, Vera Maria; Bottari, Nathieli B.; Baldissarelli, Jucimara; de Oliveira, Lizielle Souza; Goularte, Jeferson Ferraz; Belló‐Klein, Adriane; Oboh, Ganiyu; Schetinger, Maria Rosa Chitolina
• Is Part Of: Phytotherapy research. Volume 30:Number 7(2016)
• Page Start: 1156
• Page End: 1163
• Publication Date: 2016-05-06
• Subjects: Zingiber officinale -- Curcuma longa -- hypertension -- platelet -- ectonucleotidases -- ADA; Materia medica, Vegetable -- Periodicals; Botany, Medical -- Periodicals; Medicinal plants -- Periodicals; Plant Extracts -- therapeutic use -- Periodicals; Plants, Medicinal -- Periodicals; 581.634
• DOI: 10.1002/ptr.5621
• Languages: English
• ISSNs: 0951-418X

Abstract

Abstract : Hypertension is associated with platelet alterations that could contribute to the development of cardiovascular complications. Several studies have reported antiplatelet aggregation properties of ginger ( Zingiber officinale ) and turmeric ( Curcuma longa ) with limited scientific basis. Hence, this study assessed the effect of dietary supplementation of these rhizomes on platelet ectonucleotidase and adenosine deaminase (ADA) activities in N ω‐nitro‐l ‐arginine methyl ester hydrochloride (l ‐NAME) induced hypertensive rats. Animals were divided into seven groups ( n = 10): normotensive control rats; induced (l ‐NAME hypertensive) rats; hypertensive rats treated with atenolol (10 mg/kg/day); normotensive and hypertensive rats treated with 4% supplementation of turmeric or ginger, respectively. After 14 days of pre‐treatment, the animals were induced with hypertension by oral administration ofl ‐NAME (40 mg/kg/day). The results revealed a significant ( p < 0.05) increase in platelet ADA activity and ATP hydrolysis with a concomitant decrease in ADP and AMP hydrolysis ofl ‐NAME hypertensive rats when compared with the control. However, dietary supplementation with turmeric or ginger efficiently prevented these alterations by modulating the hydrolysis of ATP, ADP and AMP with a concomitant decrease in ADA activity. Thus, these activities could suggest some possible mechanism of the rhizomes against hypertension‐derived complications associated to platelet hyperactivity. Copyright © 2016 John Wiley & Sons, Ltd.