Constructing thioether‐tethered cyclic peptides via on‐resin intra‐molecular thiol–ene reaction. (5th July 2016)

• Record Type: Journal Article
• Authors: Zhao, Bingchuan; Zhang, Qingzhou; Li, Zigang
• Is Part Of: Journal of peptide science. Volume 22:Number 8(2016:Aug.)
• Page Start: 540
• Page End: 544
• Publication Date: 2016-07-05
• Subjects: intra‐molecular -- thiol–ene reaction -- thioether bond -- cyclic peptide; Peptides -- Periodicals; Peptides -- Periodicals; 572.65
• DOI: 10.1002/psc.2902
• Languages: English
• ISSNs: 1075-2617

Abstract

Abstract : Thiol–ene reactions have been used in a variety of applications that mostly involve an inter‐molecular pathway. Herein, we report a facile method to construct thioether‐tethered cyclic peptides via an intra‐molecular thiol–ene reaction. This reaction is efficient, selective, and has good residue compatibility. Short peptides with thioether tethers were constructed and were used to construct longer cyclic peptides. This synthetic method may be useful for constructing bioactive peptides. Copyright © 2016 European Peptide Society and John Wiley & Sons, Ltd. Abstract : Herein, we report a facile method to construct thioether‐tethered cyclic peptides via intra‐molecular thiol–ene reaction. This reaction is highly efficient and selective with satisfying residue compatibility.