Fabrication of V‐shaped brushes consisting of two highly incompatible arms of PEG and fluorinated PMMA and their protein‐resistance performance. Issue 16 (8th May 2016)

• Record Type: Journal Article
• Authors: Huang, Jin; He, Tingting; He, Xumiao; Xu, Jianquan; Zuo, Biao; Wang, Xinping
• Is Part Of: Journal of polymer science. Volume 54:Issue 16(2016)
• Page Start: 2599
• Page End: 2610
• Publication Date: 2016-05-08
• Subjects: adsorption -- biopolymers -- fluorinated amphiphilic polymer -- phase separation -- protein resistance -- surface -- thin films -- V‐shaped polymer brush; 547
• DOI: 10.1002/pola.28138
• Languages: English
• ISSNs: 0887-624X

Abstract

ABSTRACT: In this article, the fluorinated amphiphilic V‐shaped brushes with two highly incompatible arms of mPEG42 and PMMA38 ‐ b ‐PFMAy were produced by reacting COOH in the PAA segment in methoxypoly(ethylene glycol)‐ b ‐poly(acrylic acid)‐ b ‐poly(methyl methacrylate)‐ b ‐poly(2‐perfluoro‐octylethyl methacrylate) (mPEG42 ‐ b ‐PAA11 ‐b‐PMMA38 ‐ b ‐PFMAy ) with an epoxy group on the functionalized SiO2 substrate. It was found that the resulting phase separation structures of the V‐shaped brushes can be adjusted by altering the degree of polymerization ( y ) of PFMA. The brush surface with y = 8 showed an alternating phase separation structure, in which one domain was water‐soluble PEG and the other was ultralow surface energy domain with a crystalline fluorinated side group. Protein adsorption studies indicated that this surface structure exhibited desirable protein‐resistant performance. The reason was attributed to the stimuli‐responsive PEG domain, in which PEG chains stretch out at the interface in water, while the PFMA domain remains relatively stable. The synergistic effect of the hydrophilic PEG domain and the hydrophobic PFMA domain in water prevents protein adsorption. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem.2016, 54, 2599–2610 Abstract : The amphiphilic V‐shaped brush consisting of two highly incompatible arms of mPEG42 and PMMA38 ‐ b ‐PFMA8 were prepared. This brush surface showed an alternating phase separation structure, water‐soluble mPEG domain and poly(2‐perfluorooctylethyl methacrylate) (PFMA) domain with ultralow surface energy. The synergistic effect of the hydrophilic PEG domain and the hydrophobic PFMA domain in water prevents protein adsorption.