A Case of T‐cell Acute Lymphoblastic Leukemia Relapsed As Myeloid Acute Leukemia. Issue 9 (3rd May 2016)

• Record Type: Journal Article
• Authors: Paganin, Maddalena; Buldini, Barbara; Germano, Giuseppe; Seganfreddo, Elena; Meglio, Annamaria di; Magrin, Elisa; Grillo, Francesca; Pigazzi, Martina; Rizzari, Carmelo; Cazzaniga, Giovanni; Khiabanian, Hossein; Palomero, Teresa; Rabadan, Raul; Ferrando, Adolfo A.; Basso, Giuseppe
• Is Part Of: Pediatric blood & cancer. Volume 63:Issue 9(2016)
• Page Start: 1660
• Page End: 1663
• Publication Date: 2016-05-03
• Subjects: switch lineage -- T‐ALL -- whole‐exome sequencing; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.26054
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract : A 4‐year‐old male with the diagnosis of T‐cell acute lymphoblastic leukemia (T‐ALL) relapsed after 19 months with an acute myeloid leukemia (AML). Immunoglobulin and T‐cell receptor gene rearrangements analyses reveal that both leukemias were rearranged with a clonal relationship between them. Comparative genomic hybridization (Array‐CGH) and whole‐exome sequencing analyses of both samples suggest that this leukemia may have originated from a common T/myeloid progenitor. The presence of homozygous deletion of p16/INK4A, p14/ARF, p15/INK4B, and heterozygous deletion of WT1 locus remained stable in the leukemia throughout phenotypic switch, revealing that this AML can be genetically associated to T‐ALL.