Accelerated high‐bandwidth MR spectroscopic imaging using compressed sensing. Issue 2 (26th May 2016)

• Record Type: Journal Article
• Authors: Cao, Peng; Shin, Peter J.; Park, Ilwoo; Najac, Chloe; Marco‐Rius, Irene; Vigneron, Daniel B.; Nelson, Sarah J.; Ronen, Sabrina M.; Larson, Peder E. Z.
• Is Part Of: Magnetic resonance in medicine. Volume 76:Issue 2(2016)
• Page Start: 369
• Page End: 379
• Publication Date: 2016-05-26
• Subjects: compressed sensing -- random blip gradients -- MR spectroscopic imaging -- hyperpolarized carbon‐13 -- Hankel matrix completion -- calibrationless parallel imaging; Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.26272
• Languages: English
• ISSNs: 0740-3194

Abstract

Abstract : Purpose: To develop a compressed sensing (CS) acceleration method with a high spectral bandwidth exploiting the spatial‐spectral sparsity of MR spectroscopic imaging (MRSI). Methods: Accelerations were achieved using blip gradients during the readout to perform nonoverlapped and stochastically delayed random walks in kx ‐ky ‐t space, combined with block‐Hankel matrix completion for efficient reconstruction. Both retrospective and prospective CS accelerations were applied to 13 C MRSI experiments, including in vivo rodent brain and liver studies with administrations of hyperpolarized [1‐ 13 C] pyruvate at 7.0 Tesla (T) and [2‐ 13 C] dihydroxyacetone at 3.0 T, respectively. Results: In retrospective undersampling experiments using in vivo 7.0 T data, the proposed method preserved spectral, spatial, and dynamic fidelities with R 2 ≥ 0.96 and ≥ 0.87 for pyruvate and lactate signals, respectively, 750‐Hz spectral separation, and up to 6.6‐fold accelerations. In prospective in vivo experiments, with 3.8‐fold acceleration, the proposed method exhibited excellent spatial localization of metabolites and peak recovery for pyruvate and lactate at 7.0 T as well as for dihydroxyacetone and its metabolic products with a 4.5‐kHz spectral span (140 ppm at 3.0 T). Conclusions: This study demonstrated the feasibility of a new CS approach to accelerate high spectral bandwidth MRSI experiments. Magn Reson Med 76:369–379, 2016. © 2016 Wiley Periodicals, Inc.