A general chemical shift decomposition method for hyperpolarized 13C metabolite magnetic resonance imaging. (5th April 2016)

• Record Type: Journal Article
• Authors: Wang, Jian‐xiong; Merritt, Matthew E.; Sherry, Dean; Malloy, Craig R.
• Is Part Of: Magnetic resonance in chemistry. Volume 54:Number 8(2016:Aug.)
• Page Start: 665
• Page End: 673
• Publication Date: 2016-04-05
• Subjects: hyperpolarized -- 13C MR -- metabolite imaging -- chemical shift -- decomposition; Nuclear magnetic resonance spectroscopy -- Periodicals; Chemistry, Organic -- Periodicals; Magnetic resonance -- Periodicals; 538.36
• DOI: 10.1002/mrc.4435
• Languages: English
• ISSNs: 0749-1581

Abstract

Abstract : Metabolic imaging with hyperpolarized carbon‐13 allows sequential steps of metabolism to be detected in vivo . Potential applications in cancer, brain, muscular, myocardial, and hepatic metabolism suggest that clinical applications could be readily developed. A primary concern in imaging hyperpolarized nuclei is the irreversible decay of the enhanced magnetization back to thermal equilibrium. Multiple methods for rapid imaging of hyperpolarized substrates and their products have been proposed with a multi‐point Dixon method distinguishing itself as a robust protocol for imaging [1‐ 13 C]pyruvate. We describe here a generalized chemical shift decomposition method that incorporates a single‐shot spiral imaging sequence plus a spectroscopic sequence to retain as much spin polarization as possible while allowing detection of metabolites that have a wide range of chemical shift values. The new method is demonstrated for hyperpolarized [1‐ 13 C]pyruvate, [1‐ 13 C]acetoacetate, and [2‐ 13 C]dihydroxyacetone. Copyright © 2016 John Wiley & Sons, Ltd. Abstract : A generalized chemical shift decomposition method incorporating a single‐shot spiral imaging sequence based on Dixon method is described. This method retains as much spin polarization as possible while allowing detection of metabolites that have a wide range of chemical shift values. The method was demonstrated both in phantoms and in vivo using hyperpolarized [1‐ 13 C]pyruvate.