Polymeric Thioxanthones as Potential Anticancer and Radiotherapy Agents. Issue 13 (11th May 2016)

• Record Type: Journal Article
• Authors: Yilmaz, Gorkem; Guler, Emine; Barlas, Firat Baris; Timur, Suna; Yagci, Yusuf
• Is Part Of: Macromolecular rapid communications. Volume 37:Issue 13(2016)
• Page Start: 1046
• Page End: 1051
• Publication Date: 2016-05-11
• Subjects: anticancer -- cytotoxicity -- poly(ethylene glycol) -- poly(vinyl alcohol) -- radiotherapy -- thioxanthones; Macromolecules -- Periodicals; Polymers -- Periodicals; Chemistry -- Periodicals; 547.705
• DOI: 10.1002/marc.201600189
• Languages: English
• ISSNs: 1022-1336

Abstract

Abstract : Thioxanthone (TX) and its derivatives, which are widely used as photoinitiators in UV curing technology, hold promising research interest in biological applications. In particular, the use of TXs as anticancer agent has recently been manifested as an outstanding additional property of this class of molecules. Incorporation of TX molecules into specially designed polymers widens their practical use in such applications. In this study, two water‐soluble, biocompatible, and stable polymers, namely poly(vinyl alcohol) and poly(ethylene glycol), possessing TX moieties at the side chains and chain ends, respectively, are prepared and used as anticancer and radiotherapy agents. The findings confirm that both polymers are potential candidates for therapeutic agents as they possess useful features including water‐solubility, radiosensitizer effect, and anticancer activity in a polymeric scaffold. Abstract : Incorporation of thioxanthone (TX) molecules into specially designed polymers widens their uses in biological applications. Herein, TX moieties are chemically attached to two water‐soluble, biocompatible, and stable polymers, namely poly(vinyl alcohol) and poly(ethylene glycol) respectively, and used as anticancer and radiotherapy agents. Results confirm that both polymers exhibit enhanced activity and can be potential candidates for cancer treatment.