Longitudinal change in magnetic susceptibility of new enhanced multiple sclerosis (MS) lesions measured on serial quantitative susceptibility mapping (QSM). Issue 2 (22nd January 2016)

• Record Type: Journal Article
• Authors: Zhang, Yan; Gauthier, Susan A.; Gupta, Ajay; Comunale, Joseph; Chia‐Yi Chiang, Gloria; Zhou, Dong; Chen, Weiwei; Giambrone, Ashley E.; Zhu, Wenzhen; Wang, Yi
• Is Part Of: Journal of magnetic resonance imaging. Volume 44:Issue 2(2016)
• Page Start: 426
• Page End: 432
• Publication Date: 2016-01-22
• Subjects: multiple sclerosis -- quantitative susceptibility mapping (QSM) -- longitudinal change -- magnetic resonance imaging -- gadolinium enhancement; Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.25144
• Languages: English
• ISSNs: 1053-1807

Abstract

Abstract : Purpose: To measure the longitudinal change in multiple sclerosis (MS) lesion susceptibility using quantitative susceptibility mapping (QSM). Materials and Methods: The study was approved by our Institutional Review Board. Longitudinal changes in quantitative susceptibility values of new enhanced‐with‐Gd MS lesions were measured at baseline magnetic resonance imaging (MRI) and on a follow‐up MRI in 29 patients within 2 years using a 3D multiple echo gradient echo sequence on a 3T scanner. Paired t ‐test and the generalized estimating equations (GEE) model was used to analyze the longitudinal change. Results: Lesion susceptibility values relative to normal‐appearing white matter (NAWM) changed from 3.61 ± 6.11 ppb when enhanced‐with‐Gd at the baseline MRI to 20.42 ± 10.23 ppb when not‐enhanced‐with‐Gd at the follow‐up MRI ( P < 0.001). Conclusion: MS lesion susceptibility value increases significantly as the lesion evolves from enhanced‐with‐Gd to not‐enhanced‐with‐Gd, serving as a disease biomarker. J. Magn. Reson. Imaging 2016;44:426–432.