Caerulein‐induced pancreatitis augments the expression and phosphorylation of collapsin response mediator protein 4. (12th June 2016)

• Record Type: Journal Article
• Authors: Sato, Sho; Nakamura, Fumio; Hiroshima, Yukihiko; Nagashima, Yoji; Kato, Ikuma; Yamashita, Naoya; Goshima, Yoshio; Endo, Itaru
• Is Part Of: Journal of hepato-biliary-pancreatic sciences. Volume 23:Number 7(2016)
• Page Start: 422
• Page End: 431
• Publication Date: 2016-06-12
• Subjects: Cdk5 -- CRMP4 -- Pancreatitis -- Phosphorylation; Liver -- Diseases -- Periodicals; Biliary tract -- Diseases -- Periodicals; Pancreas -- Diseases -- Periodicals; 617.556
• DOI: 10.1002/jhbp.361
• Languages: English
• ISSNs: 1868-6974

Abstract

Abstract: Background: Chronic pancreatitis is a significant risk factor for pancreatic cancer. Previously, we demonstrated that the pancreatic cancer cells show enhanced expression of collapsin response mediator protein 4 (CRMP4) that strongly correlates with severe venous invasion, liver metastasis, and poor prognosis. However, involvement of CRMP4 in acute or chronic pancreatitis remains unknown. Methods: Acute and chronic pancreatitis mice models were developed by periodic injection of caerulein. The expression levels of CRMP4 and its phosphorylation were examined. Results: Elevated CRMP4 levels were observed in the infiltrated lymphocytes as well as in the pancreas parenchyma of both acute and chronic pancreatitis. The expression pattern of phosphorylated CRMP4 was similar to that of CRMP4. Cdk5 partially co‐localized with the phosphorylated CRMP4. Conclusions: Pancreatitis induces CRMP4 expression in the pancreas parenchyma and in the infiltrated lymphocytes. Overlapping expression of CRMP4 and Cdk5 may suggest that the Cdk5 is at least, in part, responsible for the phosphorylation of CRMP4. The results suggest that CRMP4 is involved in the inflammatory response in pancreatitis. Understanding the mechanisms of CRMP4 would help us to develop novel therapeutic strategies against acute or chronic pancreatitis, and pancreatic cancer. Abstract : Highlight Chronic pancreatitis is an important risk factor for pancreatic cancer. Sato and colleagues demonstrated that CRMP4 is expressed in chronic pancreatitis induced by caerulein in mice, suggesting that CRMP4 is involved in the inflammatory response in pancreatitis and that understanding its mechanism may lead to novel therapeutic strategies for pancreatitis.