Epigenetics in Intestinal Epithelial Cell Renewal. Issue 11 (26th April 2016)

• Record Type: Journal Article
• Authors: Roostaee, Alireza; Benoit, Yannick D.; Boudjadi, Salah; Beaulieu, Jean‐François
• Is Part Of: Journal of cellular physiology. Volume 231:Issue 11(2016:Nov.)
• Page Start: 2361
• Page End: 2367
• Publication Date: 2016-04-26
• Subjects: Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.25401
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract : A controlled balance between cell proliferation and differentiation is essential to maintain normal intestinal tissue renewal and physiology. Such regulation is powered by several intracellular pathways that are translated into the establishment of specific transcription programs, which influence intestinal cell fate along the crypt‐villus axis. One important check‐point in this process occurs in the transit amplifying zone of the intestinal crypts where different signaling pathways and transcription factors cooperate to manage cellular proliferation and differentiation, before secretory or absorptive cell lineage terminal differentiation. However, the importance of epigenetic modifications such as histone methylation and acetylation in the regulation of these processes is still incompletely understood. There have been recent advances in identifying the impact of histone modifications and chromatin remodelers on the proliferation and differentiation of normal intestinal crypt cells. In this review we discuss recent discoveries on the role of the cellular epigenome in intestinal cell fate, development, and tissue renewal. J. Cell. Physiol. 231: 2361–2367, 2016. © 2016 The Authors. Journal of Cellular Physiology Published by Wiley Periodicals, Inc. Abstract : Critical involvement of a number of key transcription factors in the control of gene expression toward the processes of intestinal cell proliferation and differentiation in the differentiating absorptive cell has been well demonstrated. However, recent data indicate that these cell processes can also be regulated by epigenetic mechanisms, such as via expression of polycomb group proteins controlling histone methylation and histone deacetylases. In this review, we analyze these mechanisms in the regulation of intestinal cell proliferation and differentiation.