Framework for human health risk assessment of non‐cancer effects resulting from short‐duration and intermittent exposures to chemicals. Issue 9 (14th June 2016)

• Record Type: Journal Article
• Authors: Haber, Lynne T.; Sandhu, Reena; Li‐Muller, Angela; Mohapatra, Asish; Petrovic, Sanya; Meek, M. E. (Bette)
• Is Part Of: Journal of applied toxicology. Volume 36:Issue 9(2016)
• Page Start: 1077
• Page End: 1089
• Publication Date: 2016-06-14
• Subjects: intermittent exposure -- framework -- short‐duration exposure -- tiered analysis -- mode of action -- toxicokinetics -- toxicodynamics; Toxicology -- Periodicals; Industrial toxicology -- Periodicals; Environmentally induced diseases -- Periodicals; Toxicology -- Periodicals; 615.9005
• DOI: 10.1002/jat.3345
• Languages: English
• ISSNs: 0260-437X

Abstract

Abstract: Durations of exposure to chemicals, whether for single, repeated or intermittent periods, may vary from those upon which most guidance values are normally based. Because it is presently not feasible to conduct toxicity studies or develop toxicity reference values (TRVs) specific to each scenario of interest, methods are needed to address these various durations, drawing as much as possible on existing TRVs. A working framework was developed to address the potential for non‐cancer effects resulting from continuous short‐duration and intermittent exposures to chemicals. The framework presents an integrated, tiered approach that assists the user in identifying when existing TRVs can be applied directly, and the adaptations needed to assess the acceptability of short‐duration or intermittent exposure scenarios. Descriptions of when and how toxicokinetic and toxicodynamic aspects need to be taken into consideration are also presented. The framework incorporates the use of TRVs based on exposure periods as similar as possible to the "actual" exposure periods and application of dose averaging under limited, specified conditions. This framework has been developed to aid in improving the scientific basis for the evaluation of short‐duration and intermittent exposures in a variety of settings. Copyright © 2016 John Wiley & Sons, Ltd. Abstract : To aid in assessing potential noncancer health effects from short‐duration and intermittent exposures, a working framework was developed utilizing a tiered approach, drawing as much as possible on existing TRVs or minor adaptations of same. Toxicokinetic and toxicodynamic considerations are included. The framework incorporates the use of TRVs based on exposure periods as similar as possible to the 'actual' exposure periods and application of dose averaging under limited, specified conditions.