Fine‐scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer. Issue 6 (17th June 2016)

• Record Type: Journal Article
• Authors: Shi, Jiajun; Zhang, Yanfeng; Zheng, Wei; Michailidou, Kyriaki; Ghoussaini, Maya; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Lush, Michael; Milne, Roger L.; Shu, Xiao‐Ou; Beesley, Jonathan; Kar, Siddhartha; Andrulis, Irene L.; Anton‐Culver, Hoda; Arndt, Volker; Beckmann, Matthias W.; Zhao, Zhiguo; Guo, Xingyi; Benitez, Javier; Beeghly‐Fadiel, Alicia; Blot, William; Bogdanova, Natalia V.; Bojesen, Stig E.; Brauch, Hiltrud; Brenner, Hermann; Brinton, Louise; Broeks, Annegien; Brüning, Thomas; Burwinkel, Barbara; Cai, Hui; Canisius, Sander; Chang‐Claude, Jenny; Choi, Ji‐Yeob; Couch, Fergus J.; Cox, Angela; Cross, Simon S.; Czene, Kamila; Darabi, Hatef; Devilee, Peter; Droit, Arnaud; Dork, Thilo; Fasching, Peter A.; Fletcher, Olivia; Flyger, Henrik; Fostira, Florentia; Gaborieau, Valerie; García‐Closas, Montserrat; Giles, Graham G.; Grip, Mervi; Guenel, Pascal; Haiman, Christopher A.; Hamann, Ute; Hartman, Mikael; Miao, Hui; Hollestelle, Antoinette; Hopper, John L.; Hsiung, Chia‐Ni; Ito, Hidemi; Jakubowska, Anna; Johnson, Nichola; Torres, Diana; Kabisch, Maria; Kang, Daehee; Khan, Sofia; Knight, Julia A.; Kosma, Veli‐Matti; Lambrechts, Diether; Li, Jingmei; Lindblom, Annika; Lophatananon, Artitaya; Lubinski, Jan; Mannermaa, Arto; Manoukian, Siranoush; Le Marchand, Loic; Margolin, Sara; Marme, Frederik; Matsuo, Keitaro; McLean, Catriona; Meindl, Alfons; Muir, Kenneth; Neuhausen, Susan L.; Nevanlinna, Heli; Nord, Silje; Børresen‐Dale, Anne‐Lise; Olson, Janet E.; Orr, Nick; van den Ouweland, Ans M.W.; Peterlongo, Paolo; Choudary Putti, Thomas; Rudolph, Anja; Sangrajrang, Suleeporn; Sawyer, Elinor J.; Schmidt, Marjanka K.; Schmutzler, Rita K.; Shen, Chen‐Yang; Hou, Ming‐Feng; Shrubsole, Matha J.; Southey, Melissa C.; Swerdlow, Anthony; Hwang Teo, Soo; Thienpont, Bernard; Toland, Amanda E.; Tollenaar, Robert A.E.M.; Tomlinson, Ian; Truong, Therese; Tseng, Chiu‐chen; Wen, Wanqing; Winqvist, Robert; Wu, Anna H.; Har Yip, Cheng; Zamora, Pilar M.; Zheng, Ying; Floris, Giuseppe; Cheng, Ching‐Yu; Hooning, Maartje J.; Martens, John W.M.; Seynaeve, Caroline; Kristensen, Vessela N.; Hall, Per; Pharoah, Paul D.P.; Simard, Jacques; Chenevix‐Trench, Georgia; Dunning, Alison M.; Antoniou, Antonis C.; Easton, Douglas F.; Cai, Qiuyin; Long, Jirong;
• Is Part Of: International journal of cancer. Volume 139:Issue 6(2016:Sep. 15)
• Page Start: 1303
• Page End: 1317
• Publication Date: 2016-06-17
• Subjects: breast cancer -- genetic susceptibility -- 8q24 -- fine‐mapping -- single nucleotide polymorphism; Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.30150
• Languages: English
• ISSNs: 0020-7136

Abstract

Abstract : Previous genome‐wide association studies among women of European ancestry identified two independent breast cancer susceptibility loci represented by single nucleotide polymorphisms (SNPs) rs13281615 and rs11780156 at 8q24. A fine‐mapping study across 2.06 Mb (chr8:127, 561, 724–129, 624, 067, hg19) in 55, 540 breast cancer cases and 51, 168 controls within the Breast Cancer Association Consortium was conducted. Three additional independent association signals in women of European ancestry, represented by rs35961416 (OR = 0.95, 95% CI = 0.93–0.97, conditional p = 5.8 × 10 −6 ), rs7815245 (OR = 0.94, 95% CI = 0.91–0.96, conditional p = 1.1 × 10 −6 ) and rs2033101 (OR = 1.05, 95% CI = 1.02–1.07, conditional p = 1.1 × 10 −4 ) were found. Integrative analysis using functional genomic data from the Roadmap Epigenomics, the Encyclopedia of DNA Elements project, the Cancer Genome Atlas and other public resources implied that SNPs rs7815245 in Signal 3, and rs1121948 in Signal 5 (in linkage disequilibrium with rs11780156, r 2 = 0.77), were putatively functional variants for two of the five independent association signals. The results highlighted multiple 8q24 variants associated with breast cancer susceptibility in women of European ancestry. Abstract : What's new? Studies comparing the entire genome have turned up multiple loci associated with breast cancer susceptibility. Generally, these genome‐wide studies identify an "index SNP, " which most strongly associates with cancer susceptibility, but does not necessarily play a functional role in tumor development. To identify additional, potentially functional, variants, this team conducted fine‐mapping analysis of the 8q24 susceptibility region. They found three additional loci significant in women of European ancestry; functional analysis revealed that two of the loci could be functionally relevant for cancer formation.