Effects of Superimposed Micro/Nano‐Structured Titanium Alloy Surface on Cellular Behaviors In Vitro1 . Issue 7 (30th March 2016)

• Record Type: Journal Article
• Authors: Wang, Teng; Wan, Yi; Liu, Zhanqiang
• Is Part Of: Advanced engineering materials. Volume 18:Issue 7(2016:Jul.)
• Page Start: 1259
• Page End: 1266
• Publication Date: 2016-03-30
• Subjects: Materials -- Periodicals; 620.11
• DOI: 10.1002/adem.201600045
• Languages: English
• ISSNs: 1438-1656

Abstract

Abstract : Surface modification has been widely applied in biomedical fields to improve the bioactivity and biocompatibility of biomedical implants. In this research, a novel superimposed micro/nano‐structured titanium alloy surface is obtained by hybrid micro‐milling technology and alkali‐hydrothermal reaction. The results indicate that substrates with micro/nano‐structure provide a beneficial interfacial environment for the growth of MC3T3s. The cell adhesion and proliferation are improved with alkali‐hydrothermal reaction. Furthermore, the superimposed micro/nano‐structured surface is conducive to induce the differentiation of MC3T3s. Conclusions demonstrate that micro/nano‐structured surface is a promising method for improving the biocompatibility of titanium alloy implants. Abstract : A novel superimposed micro/nano‐topography on titanium alloy surface is fabricated by hybrid micro‐milling technology and alkali‐hydrothermal reaction . The hydrophilicity is tremendously enhanced and the surface free energy significantly increases after surface modification. The modified implants provide a beneficial interfacial environment for the growth of osteoblasts.