Fluorofuroxans: Synthesis and Application as Photoinduced Nitric Oxide Donors. Issue 7 (30th May 2016)

• Record Type: Journal Article
• Authors: Ando, Akihiro; Matsubara, Ryosuke; Takazawa, Saori; Shimada, Toshiyuki; Hayashi, Masahiko
• Is Part Of: Asian journal of organic chemistry. Volume 5:Issue 7(2016)
• Page Start: 886
• Page End: 890
• Publication Date: 2016-05-30
• Subjects: aromatic substitution -- furoxans -- nitrogen oxides -- photochemistry -- synthetic methods; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.201600149
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: The synthesis of 3‐ and 4‐fluorofuroxans is reported for the first time. Under photoirradiation and physiological conditions, 4‐fluorofuroxans with weaker nitric oxide‐releasing ability are converted into 3‐fluorofuroxans, which show remarkable thiol‐mediated nitric oxide‐releasing properties, thereby suggesting that 4‐fluorofuroxans are potent photoinduced nitric oxide donors. Abstract : NO spells NO : 3‐ and 4‐fluorofuroxans have been synthesized for the first time. Under photoirradiation and physiological conditions, 4‐fluorofuroxans with weaker nitric oxide‐releasing ability are converted into 3‐fluorofuroxans, which show remarkable thiol‐mediated nitric oxide‐releasing properties, suggesting that 4‐fluorofuroxans are potent photoinduced nitric oxide donors.