A Family of Homo‐ and Heteroscorpionate Ligands: Applications to Bioinorganic Chemistry. Issue 15 (9th March 2016)

• Record Type: Journal Article
• Authors: Carrano, Carl J.
• Other Names: Pettinari C. guestEditor.
• Is Part Of: European journal of inorganic chemistry. Issue 15/16(2016)
• Page Start: 2377
• Page End: 2390
• Publication Date: 2016-03-09
• Subjects: Bioinorganic chemistry -- Metalloenzyme mimics -- Scorpionate ligands -- Heteroscorpionate ligands -- Molybdenum -- Zinc; Chemistry, Inorganic -- Periodicals; Organometallic chemistry -- Periodicals; Bioinorganic chemistry -- Periodicals; Solid state chemistry -- Periodicals; 546
• DOI: 10.1002/ejic.201501476
• Languages: English
• ISSNs: 1434-1948

Abstract

Abstract : In this brief review we focus on a few examples of how a family of homo‐ and heteroscorpionate ligands allow us to examine how changes in reactivity, structure, or physical/chemical properties around biologically interesting N2 X coordinated metal centers vary as a function of donor atom, charge, hydrophobicity, hydrogen bonding, etc., in a way previously unavailable. Such a family of ligands is the bioinorganic chemists answer to site‐directed mutagenesis. Here we focus on two bioinorganic examples i.e. models for molybdoenzymes and zinc metalloproteins. Abstract : A family of heteroscorpionate ligands of the form N2 X is presented where X can be interchanged between a thiolate sulfur, a pyrazole nitrogen, or a carboxylate, alkoxy or phenoxy oxygen in a series of isostructural isoelectronic metal complexes gives the bioinorganic chemist the ability to do the equivalent of "site directed mutagenesis".