Living Cell Factories ‐ Electrosprayed Microcapsules and Microcarriers for Minimally Invasive Delivery. Issue 27 (23rd December 2015)

• Record Type: Journal Article
• Authors: Naqvi, Syeda M.; Vedicherla, Srujana; Gansau, Jennifer; McIntyre, Tom; Doherty, Michelle; Buckley, Conor T.
• Is Part Of: Advanced materials. Volume 28:Issue 27(2016)
• Page Start: 5662
• Page End: 5671
• Publication Date: 2015-12-23
• Subjects: electrohydrodynamic -- hydrogels -- microcarriers -- microcapsules, core‐shell; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201503598
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : Minimally invasive delivery of "living cell factories" consisting of cells and therapeutic agents has gained wide attention for next generation biomaterial device systems for multiple applications including musculoskeletal tissue regeneration, diabetes and cancer. Cellular‐based microcapsules and microcarrier systems offer several attractive features for this particular purpose. One such technology capable of generating these types of systems is electrohydrodynamic (EHD) spraying. Depending on various parameters, including applied voltage, biomaterial properties (viscosity, conductivity) and needle geometry, complex structures and arrangements can be fabricated for therapeutic strategies. The advances in the use of EHD technology are outlined, specifically in the manipulation of bioactive and dynamic material systems to control size, composition and configuration in the development of minimally invasive micro‐scaled biopolymeric systems. The exciting therapeutic applications of this technology, future perspectives and associated challenges are also presented. Abstract : Minimally invasive delivery of "living cell factories" has gained attention in recent years. The advances in the use of electrohydrodynamic (EHD) spraying technology, capable of generating microcapsule and microcarrier systems that offer several attractive features for next‐generation biomaterial device systems are discussed, along with the exciting therapeutic applications of this technology, future perspectives, and associated challenges.