In vivo models of hepatitis B and C virus infection. Issue 13 (8th April 2016)

• Record Type: Journal Article
• Authors: Winer, Benjamin Y.; Ding, Qiang; Gaska, Jenna M.; Ploss, Alexander
• Other Names: Fackler Oliver guestEditor.; Kräusslich Hans‐Georg guestEditor.; Just Wilhelm guestEditor.
• Is Part Of: FEBS letters. Volume 590:Issue 13(2016)
• Page Start: 1987
• Page End: 1999
• Publication Date: 2016-04-08
• Subjects: hepatitis B virus -- hepatitis C virus -- hepatitis delta virus -- mouse models -- surrogate models; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.12157
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Globally, more than 500 million individuals are chronically infected with hepatitis B (HBV), delta (HDV), and/or C (HCV) viruses, which can result in severe liver disease. Mechanistic studies of viral persistence and pathogenesis have been hampered by the scarcity of animal models. The limited species and cellular host range of HBV, HDV, and HCV, which robustly infect only humans and chimpanzees, have posed challenges for creating such animal models. In this review, we will discuss the barriers to interspecies transmission and the progress that has been made in our understanding of the HBV, HDV, and HCV life cycles. Additionally, we will highlight a variety of approaches that overcome these barriers and thus facilitate in vivo studies of these hepatotropic viruses. Abstract :