Long-term prognostic significance of homocysteine in middle-aged and elderly. (17th August 2016)

• Record Type: Journal Article
• Authors: Petersen, Julie Falkenberg; Larsen, Bjørn Strøjer; Sabbah, Muhammad; Nielsen, Olav Wendelboe; Kumarathurai, Preman; Sajadieh, Ahmad
• Is Part Of: Biomarkers. Volume 21:Number 6(2016)
• Page Start: 490
• Page End: 496
• Publication Date: 2016-08-17
• Subjects: All-cause mortality -- cardiovascular disease -- plasma homocysteine; Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2016.1160288
• Languages: English
• ISSNs: 1354-750X

Abstract

Abstract: Objective : We investigated the association among increased levels of plasma homocysteine (Hcy), all-cause mortality, and cardiovascular events.Methods : Hcy was measured in 670 middle-aged and elderly subjects with no previous manifest cardiovascular disease. The follow-up period was 15 years.Results : Subjects with Hcy ≥ 10.8 μmol/l ( n = 231) had a significant higher incidence of all-cause mortality ( p < 0.001) and CV events ( p < 0.001) compared with subjects with Hcy < 10.8 μmol/l ( n = 439). However, there was no association on high levels of Hcy and VTE events or stroke.Conclusion : Increased levels of Hcy are associated with all-cause mortality and CV events.