Anti-inflammatory and immunomodulatory properties of Carica papaya. (3rd July 2016)

• Record Type: Journal Article
• Authors: Pandey, Saurabh; Cabot, Peter J.; Shaw, P. Nicholas; Hewavitharana, Amitha K.
• Is Part Of: Journal of immunotoxicology. Volume 13:Number 4(2016)
• Page Start: 590
• Page End: 602
• Publication Date: 2016-07-03
• Subjects: Anti-inflammatory -- bioactivity -- Carica papaya -- immunomodulatory -- nutraceuticals; Immunotoxicology -- Periodicals; Poisons -- Immunology -- Periodicals; Environmental health -- Periodicals; 616.97
• DOI: 10.3109/1547691X.2016.1149528
• Languages: English
• ISSNs: 1547-691X

Abstract

Abstract: Chronic inflammation is linked with the generation and progression of various diseases such as cancer, diabetes and atherosclerosis, and anti-inflammatory drugs therefore have the potential to assist in the treatment of these conditions. Carica papaya is a tropical plant that is traditionally used in the treatment of various ailments including inflammatory conditions. A literature search was conducted by using the keywords "papaya", "anti-inflammatory and inflammation" and "immunomodulation and immune" along with cross-referencing. Both in vitro and in vivo investigation studies were included. This is a review of all studies published since 2000 on the anti-inflammatory activity of papaya extracts and their effects on various immune-inflammatory mediators. Studies on the anti-inflammatory activities of recognized phytochemicals present in papaya are also included. Although in vitro and in vivo studies have shown that papaya extracts and papaya-associated phytochemicals possess anti-inflammatory and immunomodulatory properties, clinical studies are lacking.