Does the Microbiome Cause B27-related Acute Anterior Uveitis?. (3rd July 2016)

• Record Type: Journal Article
• Authors: Rosenbaum, James T.; Lin, Phoebe; Asquith, Mark
• Is Part Of: Ocular immunology and inflammation. Volume 24:Number 4(2016)
• Page Start: 440
• Page End: 444
• Publication Date: 2016-07-03
• Subjects: Ankylosing spondylitis -- HLA-B27 -- microbiome -- spondyloarthropathy -- uveitis; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.3109/09273948.2016.1142574
• Languages: English
• ISSNs: 0927-3948

Abstract

ABSTRACT: The microbiome is strongly implicated in a broad spectrum of immune-mediated diseases. Data support the concept that HLA molecules shape the microbiome. We provide hypotheses to reconcile how HLA-B27 might affect the microbiome and in turn predispose to acute anterior uveitis. These theories include bacterial translocation, antigenic mimicry, and dysbiosis leading to alterations in regulatory and effector T-cell subsets. Received 31 October 2015; revised 7 January 2016; accepted 8 January 2016; published online 22 March 2016