Precise medical decision making in geriatric anti-depressant therapy. Issue 4 (3rd July 2016)

• Record Type: Journal Article
• Authors: Gentile, Giovanna; Cipolla, Fabiola; Capi, Matilde; Simmaco, Maurizio; Lionetto, Luana; Borro, Marina
• Is Part Of: Expert review of precision medicine and drug development. Volume 1:Issue 4(2016)
• Page Start: 387
• Page End: 396
• Publication Date: 2016-07-03
• Subjects: Geriatric depression -- precision medicine -- pharmacogenomics -- drug-drug interactions -- therapeutic drug monitoring; Personalized medicine -- Periodicals; Drug development -- Periodicals; 615.19005
• DOI: 10.1080/23808993.2016.1199951
• Languages: English
• ISSNs: 2380-8993

Abstract

ABSTRACT: Introduction : Human aging is characterized by increasing vulnerability not only to diseases, but also to the treatments applied to that diseases. Geriatric depression is a frequent mental disorder often requiring pharmacological treatment, which commonly is added to other medications taken to treat chronic or acute co-morbidities. The challenges of appropriate treatment of elderly are increasingly recognized as an urgent health problem. Areas c overed : The challenges of appropriate geriatric anti-depressant prescription, and the role of novel tools developed by Precision Medicine. The data were obtained searching in MEDLINE: pharmacokinetics, pharmacodynamics, pharmacogenetics, antidepressants, drug-drug interactions and elderly, in the period 1994–2016. Expert c ommentary : The Precision Medicine approach take advantage by novel decision-supporting tools, as pharmacogenomic testing, drug-drug interactions evaluation and therapeutic drug monitoring, allowing to improve informed-decision making in prescription of antidepressants.