The rheological injectability of N-succinyl-chitosan solutions. (20th October 2016)

• Record Type: Journal Article
• Authors: Rogalsky, Allan; Kwon, Hyock Ju; Lee-Sullivan, Pearl
• Is Part Of: Carbohydrate polymers. Volume 151(2016)
• Page Start: 1082
• Page End: 1090
• Publication Date: 2016-10-20
• Subjects: N-succinyl-chitosan -- Rheology -- Synthesis -- TGA -- Polyampholyte -- Polyelectrolyte; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2016.06.029
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract : Highlights: Determined the rheological injectability limit for N-succinyl-chitosan solutions. Explained viscosity results using models proposed by Higgs and Katchalsky. Verified the existence of a regime transition predicted by Higgs model. Discovered a log-linear correlation for N-succinyl-chitosan synthesis results. Determined N-succinyl-chitosan optimum drying and thermal decomposition temperatures. Abstract: The viscosity of a set of N-succinyl-chitosan (NSC) solutions was characterized near the 0.2 Pa s rheological injectability limit. This is believed to be the first such report in the open literature. Viscosity was characterized at physiological pH and ionic strength as a function of NSC degree of substitution, NSC concentration, temperature, and shear rate. NSC was synthesized via Yamaguci's method and characterized using H-NMR, membrane osmometry, TGA and isothermal vacuum drying. NSC synthesis results were shown to fit a reproducible log-linear correlation and both optimum drying temperature and thermal decomposition temperature were found to be a function of NSC degree of substitution. Viscosity results were explained using Katchalsky's full model for polyampholyte ionization combined with a charge induced excluded volume model proposed by Higgs. The model predicted a polyelectrolyte/polyampholyte transition which agreed well with experimental data. For minimally injectable formulations a maximum in primary amine concentration is expected at 32 sub% amine NSC.