A novel method to fabricate porous tricalcium phosphate composite scaffolds for bone tissue engineering applications. (23rd August 2016)

• Record Type: Journal Article
• Authors: Sankar, Sharanya; Kumar Ramajayam, Krishna; Thirugnanam, A.
• Is Part Of: Materials technology. Volume 31:Number 10(2016)
• Page Start: 595
• Page End: 602
• Publication Date: 2016-08-23
• Subjects: Microporous scaffold -- Simulated body fluid -- Bioactivity -- Osteointegration; Materials -- Periodicals; Materials science -- Periodicals; Materials -- Technological innovations -- Periodicals; 620.1105
• DOI: 10.1080/10667857.2016.1151194
• Languages: English
• ISSNs: 1066-7857

Abstract

Abstract : This study reports a novel approach for the fabrication of three-dimensional scaffolds using tricalcium phosphate, carboxymethyl cellulose composite with alginate. Microporous (<20 μm) scaffold fibres were made by incorporating gas bubbles within fibres, stabilizing it with surfactants and subsequently removing the gas by vacuum treatment. The morphology of the scaffold was characterized using scanning electron microscopy (SEM). Further, for quantitative determination of pore size, the porosity distribution of the scaffold fibre was determined using mercury intrusion porosimetry (MIP). The volume porosity of these scaffolds was determined by liquid displacement method. Compressive strength, rigidity constant and stiffness index of the constructs were also determined. The in vitro bioactivity studies of these scaffolds were carried out in simulated body fluid (SBF) for 2/4 weeks. This study showed that the scaffold provides a favourable substrate conditions to form a bone-like mineral phase, which might play a significant role in osteointegration.