Probing inclusion complexes of cyclodextrins with amino acids by physicochemical approach. (20th October 2016)

• Record Type: Journal Article
• Authors: Roy, Mahendra Nath; Roy, Aditi; Saha, Subhadeep
• Is Part Of: Carbohydrate polymers. Volume 151(2016)
• Page Start: 458
• Page End: 466
• Publication Date: 2016-10-20
• Subjects: Inclusion complex -- Cyclodextrin -- Amino acid -- Spectroscopic investigation -- Physicochemical studies -- Thermodynamic parameter; α-Cyclodextrin (PubChem CID: 444913) -- β- (PubChem CID: 444041) -- l-Leucine (PubChem CID: 6106) -- l-Isoleucine (PubChem CID: 6306); Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2016.05.100
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: α and β-Cyclodextrin form inclusion complex withl -Leu andl -Ile in aqueous media. Surface tension and conductivity studies suggest 1:1 stoichiometry of the complex. Density, viscosity and refractive index studies show the host-guest interactions. Hydration number and solvation number also support the inclusion phenomenon. Stability constants are calculated from NMR titration. Abstract: Formations of host-guest inclusion complexes of two natural amino acids, viz., l -Leucine andl -Isoleucine as guests with α and β-cyclodextrins have been investigated which include diverse applications in modern science such as controlled delivery in the field of pharmaceuticals, food processing etc. Surface tension and conductivity studies establish the formation of inclusion complexes with 1:1 stoichiometry. The interactions of cyclodextrins with amino acids have been supported by density, viscosity, refractive index, hydration and solvation number measurements indicating higher degree of inclusion in case of α-cyclodextrin.l -Leucine interacts more with the hydrophobic cavity of cyclodextrin than its isomer. With the help of stability constant by NMR titration, hydrophobic effect, H-bonds and structural effects the formations of inclusion complexes have been explained.