Humanin: Functional Interfaces with IGF-I. (August 2016)

• Record Type: Journal Article
• Authors: Xiao, J.; Kim, S.-J.; Cohen, P.; Yen, K.
• Is Part Of: Growth hormone & IGF research. Volume 29(2016)
• Page Start: 21
• Page End: 27
• Publication Date: 2016-08
• Subjects: Humanin -- IGF-I -- Growth hormone -- Mitochondria -- Neuroprotection -- Peptide; Growth regulators -- Periodicals; Growth -- Regulation -- Periodicals; Somatomedin -- Periodicals; Somatomedins -- Periodicals; Growth Hormone -- Periodicals; Growth Substances -- Periodicals; Croissance -- Régulation -- Périodiques; Croissance -- Régulateurs -- Périodiques; Somatotrophine -- Périodiques; Somatomédine -- Périodiques; Growth -- Regulation; Growth regulators; Electronic journals; Periodicals; Electronic journals; 612.4
• DOI: 10.1016/j.ghir.2016.03.005
• Languages: English
• ISSNs: 1096-6374

Abstract

Abstract: Humanin is the first newly discovered peptide encoded in the mitochondrial genome in over three decades. It is the first member of a novel class of mitochondrial derived peptides. This small, 24 amino acid peptide was initially discovered to have neuroprotective effects and subsequent experiments have shown that it is beneficial in a diverse number of disease models including stroke, cardiovascular disease, and cancer. Over a decade ago, our lab found that humanin bound IGFBP-3 and more recent studies have found it to decrease circulating IGF-I levels. In turn, IGF-I also seems to regulate humanin levels and in this review, we cover the known interaction between humanin and IGF-I. Although the exact mechanism for how humanin and IGF-I regulate each other still needs to be elucidated, it is clear that humanin is a new player in IGF-I signaling. Highlights: Humanin is a new player in the regulation of the GH-IGF axis. IGFBP-3 interacts with humanin to influence both IGF-I and humanin bioavailability. Humanin is the first member of a novel class of peptides encoded within small open reading frames in the mitochondrial genome. Humanin has also been shown to have neuroprotective and cytoprotective effects. Humanin decreases circulating IGF-I levels in mouse studies, having a diet-restriction-mimetic effect.