Clinical significance of acquired loss of the X chromosome in bone marrow. (August 2016)

• Record Type: Journal Article
• Authors: Tang, Zhenya; Li, Yan; Wang, Sa A.; Hu, Shimin; Li, Shaoying; Lu, Xinyan; Khoury, Joseph D.; Medeiros, L. Jeffrey; Tang, Guilin
• Is Part Of: Leukemia research. Volume 47(2016:Aug.)
• Page Start: 109
• Page End: 113
• Publication Date: 2016-08
• Subjects: Acquired loss of X chromosome -- Combined morphologic-FISH analysis -- Myeloid neoplasms -- Aging effect -- Disease-related; Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2016.05.023
• Languages: English
• ISSNs: 0145-2126

Abstract

Highlights: Is a rare finding and only detected in women. Usually presents as a minor clone and is likely age-related or a benign finding. Could be associated with myeloid neoplasms when it presents as a major clone. Abstract: Acquired loss of the X chromosome (-X) as a sole abnormality is detected rarely in bone marrow (BM) and its clinical importance remains largely unknown. We studied 38 patients with isolated -X in BM. All patients were women, with a median age of 71 years. At the time of -X detection, BM was positive for myeloid neoplasm in 14 patients, lymphoma/myeloma in 10 patients, and was normal in 14 patients. -X was detected as a major clone in 15 patients (11 of them had myeloid neoplasm) and a minor clone in 23 patients. Combined morphologic and FISH analysis was performed in 16 cases, -X was detected in myeloid/erythroid cells in all 16 patients and in lymphocytes in 15 patients. With a median of 23 months follow-up, none of the patients with a negative BM or BM with involvement by lymphoid neoplasms developed a secondary myeloid neoplasm. We conclude that isolated -X is a rare finding in BM. In majority of patients, -X presents as a minor clone and is likely to be an aging effect or a benign finding; whereas when -X presents as a major clone in BM, it is often disease associated.