ADAMTS4 and Oxidative/Antioxidative Status in Preterm Premature Rupture of Membranes. (3rd July 2016)

• Record Type: Journal Article
• Authors: Ozler, Sibel; Oztas, Efser; Guler, Basak Gumus; Ergin, Merve; Uygur, Dilek; Yucel, Aykan; Erel, Ozcan; Danisman, Nuri
• Is Part Of: Fetal and pediatric pathology. Volume 35:Number 4(2016)
• Page Start: 239
• Page End: 250
• Publication Date: 2016-07-03
• Subjects: ADAMTS4 -- TAS -- TOS -- ARES -- PPROM -- amniotic membranes; Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.1080/15513815.2016.1175529
• Languages: English
• ISSNs: 1551-3815

Abstract

ABSTRACT: Aim: To determine the function of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS4), total oxidant status (TOS), total antioxidant status (TAS), and aryl esterase (ARES) in preterm premature rupture of membranes (PPROM) and to investigate the association with premature rupture of membranes (PROMs). Material and Methods: 58 pregnant women were included in this prospective study which comprised 29 PPROM patients as the study group and 29 patients, having healthy amniotic membranes, as the control group. ADAMTS4, TAS, TOS, and ARES levels were studied in the amniotic membrane homogenates of the patients. Results: ADAMTS4, TAS TOS, and ARES levels of amniotic membrane lysates were significantly different between PPROM and control groups ( p < 0.001, p < 0.001, p = 0.008 and p = 0.002, respectively). Increased amniotic membrane ADAMTS4 (OR: 1.051 95% CI 1.006–1.098, p = 0.024) and TOS (OR: 12.777 95% CI 1.595–102.323, p = 0.016) were found to be significantly associated with the increased risk of PPROM. Conclusion: ADAMTS4, TOS, and ARES levels were higher and TAS level was lower in PPROM patients than the normal healthy control group which had healthy amniotic membranes at term. As a result, ADAMTS4 may have a role in the pathogenesis by causing increased oxidative and inflammatory environment in PPROM.