Propylphosphonic anhydride (T3P®) mediated one-pot three-component synthesis of racemic dialkyl (2-substituted-3-oxo-2, 3-dihydro-1H-isoindol-1-yl)phosphonates. Issue 33 (18th August 2016)

• Record Type: Journal Article
• Authors: Milen, Mátyás; Dancsó, András; Földesi, Tamás; Slégel, Péter; Volk, Balázs
• Is Part Of: Tetrahedron. Volume 72:Issue 33(2016)
• Page Start: 5091
• Page End: 5099
• Publication Date: 2016-08-18
• Subjects: α-Aminophosphonates -- Oxoisoindoles -- T3P® -- Three-component reaction -- Modified Kabachnik-Fields condensation; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2016.06.074
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: A practical and efficient synthesis of racemic dialkyl (2-substituted-3-oxo-2, 3-dihydro-1 H -isoindol-1-yl) phosphonates has been developed via the three-component reaction of 2-formylbenzoic acid, various primary amines and trialkyl phosphites, using propylphosphonic anhydride (T3P ® ) as the condensing agent. The one-pot reaction was easily performed in boiling ethyl acetate. Graphical abstract: