Minor salivary glands function is decreased in hyposalivation-related diseases. (September 2016)

• Record Type: Journal Article
• Authors: Wang, Zhen; Li, Wei; Hong, Xia; Su, Jia-Zeng; Hua, Hong; Peng, Xin; Lv, Lan; Yu, Guang-Yan
• Is Part Of: Archives of oral biology. Volume 69(2016)
• Page Start: 63
• Page End: 70
• Publication Date: 2016-09
• Subjects: pSS primary Sjögren's syndrome -- IgG4-RS IgG4-related sialadenitis -- RTDM radiation therapy-induced dry mouth -- SJS Steven–Johnson syndrome -- HNC head and neck cancer -- MSG minor salivary gland -- SXI summated xerostomia inventory; Minor salivary gland hypofunction -- Salivary flow rate -- Sjögren's syndrome -- IgG4-related sialadenitis -- Radiation therapy-induced dry mouth -- Dry mouth; Mouth -- Periodicals; Mouth -- Diseases -- Periodicals; Dentistry -- Periodicals; Electronic journals; 617.6005
• DOI: 10.1016/j.archoralbio.2016.05.012
• Languages: English
• ISSNs: 0003-9969

Abstract

Highlights: MSG function is affected in 4 disease conditions. MSG function in 4 disease conditions is more preserved than major salivary gland. Xerostomia degrees differ among the four disease conditions. MSG flow rates showed no correlation with SXI scores in 4 disease conditions. Abstract: Objectives: The aim of this cross-sectional study was to investigate the relationship between minor salivary gland (MSG) flow rates and oral dryness degrees in patients with xerostomia induced by primary Sjögren's syndrome (pSS), IgG4-related sialadenitis (IgG4-RS), radiation therapy-induced dry mouth (RTDM), or Steven–Johnson syndrome (SJS). Design: 160 patients with pSS, IgG4-RS, RTDM, or SJS and their age- and sex-matched healthy control subjects were enrolled. The whole saliva flow rates and MSG flow rates were measured in four locations, including the upper labial, lower labial, buccal, and palatal mucosae. The degree of oral dryness was assessed in patient groups using the summated xerostomia inventory (SXI). Results: The flow rates of whole saliva and most MSGs in patient groups were significantly lower than the flow rates in healthy control groups ( P < 0.05). The mean relative percentage of decrease in saliva flow rates was smaller in MSGs than in whole saliva in patient groups ( P < 0.05), indicating that these disorders have less impact on MSGs. Among the four MSG locations (the upper labial, lower labial, buccal, and palatal), buccal glands showed the highest flow rates in patient groups ( P < 0.05). SXI scores were significantly higher in pSS and RTDM patients than in IgG4-RS and SJS patients ( P < 0.05). The degree of xerostomia varied among different patient groups ( P < 0.05) and there was no clear correlation between MSG flow rates and SXI scores ( P > 0.05). Conclusions: MSG function is significantly reduced in pSS, RTDM, IgG4-RS, and SJS patients, but this reduction is more pronounced in the major salivary glands.