Inhaled aerosol dosimetry: Some current research needs. (September 2016) - Darquenne, Chantal
Abstract: After the presentation of 60 papers at the conference "Advancing Aerosol Dosimetry Research" (October 24–25, 2014 in Irvine, CA, USA), attendees submitted written descriptions of needed research. About 40 research needs were submitted. The suggestions fell into six broad categories: 1) Access to detailed anatomic data; 2) Access to subject-specific aerosol deposition datasets; 3) Improving current inhaled aerosol deposition models; 4) Some current experimental data needs and hot topics; 5) Linking exposure and deposition modeling to health endpoints; and 6) Developing guidelines for appropriate validation of dosimetry and risk assessment models. Summaries of suggestions are provided here as an update on research needs related to inhaled aerosol dosimetry modeling. Taken together, the recommendations support the overarching need for increased collaborations between dose modelers and those that use the models for risk assessments, aerosol medicine applications, design of toxicology experiments, and extrapolation across species. This paper is only a snapshot in time of perceived research needs from the conference attendees; it does not carry the approval of any agency or other group that plans research priorities or that funds research. Highlights: New major advances in aerosol dose modeling will need an interdisciplinary approach. Deposition modeling predictions need to be linked to health endpoints. Guidelines for appropriate validation of dosimetry models need to be developed.