Synthesis, crystal structure, and Helicobacter pylori urease inhibition of a dicyanoamide bridged Cu(I/II) complex. Issue 16 (17th August 2016)

• Record Type: Journal Article
• Authors: Zhu, Yueyang; Wang, Cun-Fang; Yan, Kai; Zhao, Ke-Dong; Sheng, Gui-Hua; Hu, Qiqige; Zhang, Leiyu; You, Zhonglu
• Is Part Of: Journal of coordination chemistry. Volume 69:Issue 16(2016)
• Page Start: 2493
• Page End: 2499
• Publication Date: 2016-08-17
• Subjects: Copper complex -- 5-methylsalicylaldehyde -- 2, 2′-bipyridine -- crystal structure -- urease inhibition; Coordination compounds -- Periodicals; 541.2242
• DOI: 10.1080/00958972.2016.1186801
• Languages: English
• ISSNs: 0095-8972

Abstract

Abstract: A dicyanoamide-bridged polymeric copper(I/II) complex, [Cu II (sal)(bipy)Cu I (dca)2 ]n, was prepared by reaction of 5-methylchlorosalicylaldehyde (Hsal), 2, 2′-bipyridine (bipy), sodium dicyanoamide (Nadca), and copper perchlorate in methanol. The complex was characterized by elemental analyses, infrared and electronic spectroscopy, and single-crystal X-ray determination. Cu II has a square pyramidal coordination, and Cu I has triangular coordination. The complex showed high urease inhibitory activity with IC50 value of 0.16 ± 0.23 μM. Abstract :