A facile and effective procedure for the synthesis of 4-thiazolidinone derivatives using Y(OTf)3 as catalyst. (3rd July 2016)

• Record Type: Journal Article
• Authors: Luo, Juan; Zhong, Zijun; Ji, Hongfu; Chen, Jiayin; Zhao, Jun; Zhang, Furen
• Is Part Of: Journal of sulfur chemistry. Volume 37:Number 4(2016)
• Page Start: 438
• Page End: 449
• Publication Date: 2016-07-03
• Subjects: Three-component reaction -- 4-thiazolidinones -- thioglycolic acid -- 1, 3-oxathiolan-5-ones -- yttrium triflate; Sulfur -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.72305
• DOI: 10.1080/17415993.2016.1161045
• Languages: English
• ISSNs: 1741-5993

Abstract

ABSTRACT: A one-pot three-component reaction for the synthesis of 4-thiazolidinone derivatives has been established by reacting readily available and inexpensive starting materials of amines, aldehydes and thioglycolic acid using Y(OTf)3 (5 mol%) as catalyst in tetrahydrofuran. This method is very efficient due to low catalyst loading and mild reaction conditions and provides an efficient and promising synthetic strategy for the construction of the thiazolidinone skeleton. GRAPHICAL ABSTRACT: