Electrogenerated base-promoted synthesis and antimicrobial activity of 2-imino-1, 3-thiazolidin-4-one derivatives. (3rd July 2016)

• Record Type: Journal Article
• Authors: Haouas, Beya; Saied, Taieb; Ayari, Hanen; Arfaoui, Youssef; Benkhoud, Mohamed Lamine; Boujlel, Khaled
• Is Part Of: Journal of sulfur chemistry. Volume 37:Number 4(2016)
• Page Start: 391
• Page End: 400
• Publication Date: 2016-07-03
• Subjects: Thiourea -- thiazolidinone -- acetonitrile -- electrogenerated base -- antimicrobial activity; Sulfur -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.72305
• DOI: 10.1080/17415993.2016.1155588
• Languages: English
• ISSNs: 1741-5993

Abstract

ABSTRACT: Electrogenerated cyanomethylanions obtained by reduction of dry acetonitrile at a steel grid cathode were used to promote the addition of ethyl bromoacetate to thiourea derivatives. The reaction yields the corresponding 2-imino-1, 3-thiazolidin-4-one. The reaction pathway was discussed based on the kinetic and thermodynamic data obtained by computational methods. In addition, the biological activity of these new compounds was also investigated. GRAPHICAL ABSTRACT: